L-carnitine increases walking distance in patients with peripheral artery disease. One study of people with type 2 diabetes taking anti-diabetic medication indicated that carnitine supplements significantly reduced blood sugar levels, compared to a placebo (55). View abstract. 244 Jackson Street. Effect de la L-carnitine chez les patients en hemodialyse chronique traite e par erythropoietine recombinante [abstract]. Lancet 10-11-1980;2(8198):763-764. Roy, M. J., Dionne, S., Marx, G., Qureshi, I., Sarma, D., Levy, E., and Seidman, E. G. In vitro studies on the inhibition of colon cancer by butyrate and carnitine. Effects of L-carnitine administration on left ventricular remodeling after acute anterior myocardial infarction: the L-Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) Trial. Biomed Pharmacother. 8588 Background: Carnitine is a natural aminoacid derivative that plays a crucial role in cellular energy metabolism. 1998;32(2):258-264. Relative bioavailability of carnitine supplementation in premature neonates. Since L-carnitine helps move more fatty acids into your cells to be burned for energy, you might think this would increase your ability to burn fat and lose weight. 1999; Mitwalli, A. H., Al-Wakeel, J. S., Alam, A., Tarif, N., Abu-Aisha, H., Rashed, M., and Al, Nahed N. L-carnitine supplementation in hemodialysis patients. Nootropics are drugs or supplements that can boost brain function. Effect of PLC on functional parameters and oxidative profile in type 2 diabetes-associated PAD. Cochrane.Database.Syst.Rev. View abstract. View abstract. Baudouin C, Labb A, Liang H, Pauly A, Brignole-Baudouin F. Preservatives in eyedrops: the good, the bad and the ugly. View abstract. Ann.Nutr.Metab 2008;53(2):91-95. View abstract. Cochrane.Database.Syst.Rev. Acta Paediatr 1995;84:93-5. Check with your doctor as soon as possible if any of the following side effects occur while taking levocarnitine: Some side effects of levocarnitine may occur that usually do not need medical attention. The early effects of intravenous L-propionyl carnitine on ulcerative trophic lesions of the lower limbs in arteriopathic patients: a controlled randomized study. Heart complications (such as irregular heartbeat and heart failure). 2020;12(5):e7982. Gunal, A. I., Celiker, H., Donder, E., and Gunal, S. Y. 2-8-2006;107(1):54-60. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Digiesi, V., Palchetti, R., and Cantini, F. [The benefits of L-carnitine therapy in essential arterial hypertension with diabetes mellitus type II]. View abstract. Am J Clin Nutr 1990;52(5):889-894. Beneficial effects of L-carnitine in myoblastic C2C12 cells. Nephrol.Dial Transplant 2008;23(3):991-997. 1986;13(6):268-276. View abstract. Cardiovasc.Drugs Ther 1999;13:537-46. . L-Carnitine Tartrate Supplementation for 5 Weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial. Reported side effects are unusual, but include insomnia, headache, diarrhea, low or high blood pressure, nausea, blurred vision, and chest pains. Am.J Hypertens. How Much Caffeine Is Okay? Plasma carnitine deficiency: Clinical observations in 51 pediatric patients. View abstract. Patrikarea A, Stamatelow K Ntaountaki I Papadakis IT. View abstract. Zhonghua Nan.Ke.Xue. Nilsson-Ehle, P., Cederblad, G., Fagher, B., Monti, M., and Thysell, H. Plasma lipoproteins, liver function and glucose metabolism in haemodialysis patients: lack of effect of L-carnitine supplementation. It is well-known that insomnia often occurs in the setting of various social stressors (e.g., personal loss, social disruption), mental and physical health problems (e.g., heart disease, depression) and in those with a family history of the condition (see Risk Factors for Insomnia ). Another human study monitored L-carnitines effect on fat burning during a 90-minute stationary bicycle workout. J Interferon Cytokine Res 2011;31(9):653-659. Tumori 2005;91(2):135-138. HIV.Med. Salonia, A. CNS.Drugs 2007;21 Suppl 1:25-30. Asbaghi O, Kashkooli S, Amini MR, et al. Rebuzzi AG, Schiavani G, Amico C, and et al. 1996;208(3):129-134. L-carnitine and platelet aggregation in uremic patients subjected to hemodialysis. View abstract. Am J Clin Nutr 1981;34(8):1496-1500. Cavallini G, Caracciolo S, Vitali G, et al. Zhonghua Er.Ke.Za Zhi. Derosa, G., Maffioli, P., Salvadeo, S. A., Ferrari, I., Gravina, A., Mereu, R., D'Angelo, A., Palumbo, I., Randazzo, S., and Cicero, A. F. Sibutramine and L-carnitine compared to sibutramine alone on insulin resistance in diabetic patients. View abstract. Xie, H., Tang, S. Y., Li, H., Luo, X. H., Yuan, L. Q., Wang, D., and Liao, E. Y. L-carnitine protects against apoptosis of murine MC3T3-E1 osteoblastic cells. Cell Death.Dis 2010;1:e62. Alternative medical interventions used in the treatment and management of myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia. Vaux, E. C., Taylor, D. J., Altmann, P., Rajagopalan, B., Graham, K., Cooper, R., Bonomo, Y., and Styles, P. Effects of carnitine supplementation on muscle metabolism by the use of magnetic resonance spectroscopy and near-infrared spectroscopy in end-stage renal disease. Int J Clin Pharmacol Res 1990;10:101-7. View abstract. According to this work, published online in the journal Nature Medicine, eating red meat delivers L-carnitine to bacteria that live in the human gut. Nausea and vomiting Diarrhea Other possible side effects may include: Headaches and dizziness Insomnia Fatigue Skin itching or rashes Irritability or agitation The safety of use of CoQ10 during pregnancy and breast-feeding hasn't been established. An JH, Kim YJ, Kim KJ, et al. Pola P, Tondi P, Dal Lago A, and et al. Orlando G and Rusconi C. Oral L-carnitine in the treatment of chronic cardiac ischaemia in elderly patients. 150mg ala, and 500mg carnitine. L-Carnitine may also be used for purposes not listed in this medication guide. Clin Ter. View abstract. View abstract. 2009;37(4):622-631. View abstract. 2006;39(4):465-474. Cell Biol.Int. J Androl 2004;25(5):761-770. View abstract. Learn how to separate fact from fiction in the world of weight loss. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease. Avoid taking ALCAR too late in the day, as it can cause insomnia in some people. Jirillo, E., Altamura, M., Munno, I., Pellegrino, N. M., Sabato, R., Di Fabio, S., and De Simone, C. Effects of acetyl-L-carnitine oral administration on lymphocyte antibacterial activity and TNF-alpha levels in patients with active pulmonary tuberculosis. Neuro.Endocrinol.Lett. Pharmacol Res 1998;37(2):115-122. View abstract. Pesce, V., Fracasso, F., Cassano, P., Lezza, A. M., Cantatore, P., and Gadaleta, M. N. Acetyl-L-carnitine supplementation to old rats partially reverts the age-related mitochondrial decay of soleus muscle by activating peroxisome proliferator-activated receptor gamma coactivator-1alpha-dependent mitochondrial biogenesis. 2009;19(1):Pe11-Pe15. Foitzik, K., Hoting, E., Heinrich, U., Tronnier, H., and Paus, R. Indications that topical L-carnitin-L-tartrate promotes human hair growth in vivo. Spiering, B. L-carnitine has most often been used by adults in doses of 2 grams by mouth daily. View abstract. Weinhandl, E. D., Rao, M., Gilbertson, D. T., Collins, A. J., and Pereira, B. J. Muscle carnitine deficiency in patients using valproic acid. South Med J 1993;86:1411-2. Treatment with acetyl L-carnitine also appeared to protect these mice, suggesting that a similar preventative approach might work for depression-prone people. View abstract. Tanner, L. M., Nanto-Salonen, K., Rashed, M. S., Kotilainen, S., Aalto, M., Venetoklis, J., Niinikoski, H., Huoponen, K., and Simell, O. Carnitine deficiency and L-carnitine supplementation in lysinuric protein intolerance. Saudi.J Kidney Dis Transpl. Speak with a healthcare provider to find out what dose might be best for a specific condition. Int.J Sport Nutr.Exerc.Metab 2008;18(1):19-36. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Nephrol Dial.Transplant. Wang, S. B., Weng, W. C., Lee, N. C., Hwu, W. L., Fan, P. C., and Lee, W. T. Mutation of mitochondrial DNA G13513A presenting with Leigh syndrome, Wolff-Parkinson-White syndrome and cardiomyopathy. View abstract. If you have one of these conditions, a supplement may be beneficial (1, 66, 67). View abstract. 2007;19(2):206-210. Nasser, M., Javaheri, H., Fedorowicz, Z., and Noorani, Z. Carnitine supplementation for inborn errors of metabolism. Am J Clin Nutr 1980;33(7):1489-1492. Editorial comment on: Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. Call your doctor for medical advice about side effects. [Effect of L-carnitine on post-stress metabolism in surgical patients]. Maebashi, M., Kawamura, N., Sato, M., Imamura, A., and Yoshinaga, K. Lipid-lowering effect of carnitine in patients with type-IV hyperlipoproteinaemia. Turpeinen, A. K., Kuikka, J. T., Vanninen, E., Yang, J., and Uusitupa, M. I. There is little evidence that L-carnitine supplementation improves cancer -related fatigue, low fertility, or overall physical health. Metabolism 2010;59(8):1190-1199. View abstract. These 11 healthy foods can help you burn fat. Clin Pharmacol Ther 1994;55(6):681-692. [v] Gibault, J. P., Frey, A., Guiraud, M., Schirardin, H., Bouletreau, P., and Bach, A. C. Effects of L-carnitine infusion on intralipid clearance and utilization. J Inherit.Metab Dis 2008;31 Suppl 2:S453-S456. Does left ventricular function improve with L-carnitine after acute myocardial infarction? Mov Disord. These symptoms are not considered to be severe side effects. Medicine (Baltimore). In a preliminary analysis, we reported that L-carnitine could improve fatigue, mood and sleep. Systematic review of pharmacological treatments in fragile X syndrome. View abstract. View abstract. Cardiovasc Drugs Ther 1990;4:481-6. Intern.Med 2010;49(16):1717-1725. Effects of L- and DL-carnitine on patients with impaired exercise tolerance. View abstract. Molyneux, R., Seymour, A. M., and Bhandari, S. Value of carnitine therapy in kidney dialysis patients and effects on cardiac function from human and animal studies. There have been a few studies on acetyl-L-carnitine's use as a treatment. Ahmad S, Robertson HT, Golper TA, et al. View abstract. The highest concentrations are in high energy demand areas such as your brain, heart and muscles. Ricci, A., Caiati, C., Galantino, A., Scrutinio, D., Valentini, G., Chiddo, A., and Rizzon, P. [Acute effects of propionyl-L-carnitine on anomalies of parietal kinetics of the left ventricle induced by atrial pacing in patients with ischemic heart disease. View abstract. Metabolic rates vary by individual. For most people, 2 grams or less per day is relatively safe and free from any serious side effects. 2006;176(4 Pt 1):1307-1312. A., and Loprinzi, C. L. A critical review of complementary therapies for cancer-related fatigue. You may report side effects to FDA at 1-800-FDA-1088. Iyer, R., Gupta, A., Khan, A., Hiremath, S., and Lokhandwala, Y. J Inherit.Metab Dis 2008;31(4):503-507. View abstract. View abstract. 2012;13(2):285-293. View abstract. Young, P., Finn, B. C., Alvarez, F., Bruetman, J. E., and Trimarchi, H. [Valproate-associated hyperammonemic encephalopathy. Fulgente T, Onofrj M Del Re ML et al. J Physiol Biochem. J Nutr.Biochem. View abstract. L-carnitine is also linked to improvements in patients with severe heart disorders, such as coronary heart disease and chronic heart failure (40, 41). 2000;22(1):73-80. View abstract. Fan, J. P., Kim, H. S., and Han, G. D. Induction of apoptosis by L-carnitine through regulation of two main pathways in Hepa1c1c 7 cells. This thread is archived Clin Lymphoma Myeloma Leuk. View abstract. View abstract. Dokmeci, D., Inan, M., Basaran, U. N., Yalcin, O., Aydogdu, N., Turan, F. N., and Uz, Y. H. Protective effect of L-carnitine on testicular ischaemia-reperfusion injury in rats. 1-1-2010;84(1):52-58. Mingrone G, Greco AV, Capristo E, et al. View abstract. View abstract. Brand names: Carnitor, L-Carnitine Pediatr.Res. Nutr Metab Cardiovasc Dis 2019;29(11):1151-67. doi: 10.1016/j.numecd.2019.07.012. It has been reported to cause vomiting, diarrhea, a fishy body odor, abdominal cramps, and nausea. View abstract. View abstract. Relative carnitine deficiency in autism. Nephron 1997;75(3):372. 2014 May;29(5):997-1004. Exp Clin Endocrinol Diabetes. J Pediatr 1986;109(6):984-988. Kletzmayr J, Mayer G, Legenstein E, et al. Common L-carnitine side effects include stomach pain, nausea, vomiting and diarrhea. 2017;25(1):13-4. Pharmacol Res 1991;23:241-6. Does oral L-carnitine alter plasma triglyceride levels in hypertriglyceridaemic subjects with or without non-insulin dependent diabetes mellitus? Int J Curr Res Acad Rev 2015;3:469-76. L-carnitine may increase the risk of seizures in those with epilepsy. Dig.Dis Sci 2006;51(12):2242-2247. Several natural foods and beverages have been shown to increase metabolism and promote fat loss. Marconi C, Sassi G, Carpinelli A, Cerretelli P. Effects of L-carnitine loading on the aerobic and anaerobic performance of endurance athletes. View abstract. A case of hemoperfusion and L-carnitine management in valproic acid overdose. Drug Dev Res 1988;14:213-216. Patients with medium-chain acyl-coenzyme a dehydrogenase deficiency have impaired oxidation of fat during exercise but no effect of L-carnitine supplementation. Kang, H. C., Kim, H. D., Lee, Y. M., and Han, S. H. Landau-Kleffner syndrome with mitochondrial respiratory chain-complex I deficiency. In cells, it helps transport fatty acids into the mitochondria, where they can be burned for energy. The effects of L-carnitine supplementation on lipid concentrations inpatients with type 2 diabetes: A systematic review and meta-analysis of randomized clinical trials. Bipolar.Disord. View abstract. View abstract. Some animal studies suggest that the acetyl form, acetyl-L-carnitine (ALCAR), may help prevent age-related mental decline and improve markers of learning (30, 31). Bloomer, R. J., Tschume, L. C., and Smith, W. A. Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects. Multicenter clinical placebo-controlled study with acetyl-L-carnitine in the treatment of mildly demented elderly patients. View abstract. Mantero MA, Barbero M, Giannini R, and et al. Potential involvement of altered carnitine palmitoyltransferase-I activity. Sabry, A. View abstract. Chinese J.Pract.Internal Med. Ovidius University Annals, Physical Education and Sport/Science, Movement and Health Series 2010;10(Suppl 2):504-507. 2014 Feb;99(2):408-22. Int.Angiol. Kraft, M., Kraft, K., Gartner, S., Mayerle, J., Simon, P., Weber, E., Schutte, K., Stieler, J., Koula-Jenik, H., Holzhauer, P., Grober, U., Engel, G., Muller, C., Feng, Y. S., Aghdassi, A., Nitsche, C., Malfertheiner, P., Patrzyk, M., Kohlmann, T., and Lerch, M. M. L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN)--a randomized multicentre trial. Sherif NA, El-Banna AS, ElBourini MM, Khalil NO. View abstract. View abstract. Br.J Clin Pharmacol 2007;64(3):335-345. Huang H, Song L, Zhang H, Zhang H, Zhang J, Zhao W. Influence of L-carnitine supplementation on serum lipid profile in hemodialysis patients: a systematic review and meta-analysis. Graziano F, Bisonni R, Catalano V, et al. 2009;48(5):587-596. View abstract. 2011;60(1):85. Duranay, M., Akay, H., Yilmaz, F. M., Senes, M., Tekeli, N., and Yucel, D. Effects of L-carnitine infusions on inflammatory and nutritional markers in haemodialysis patients. Carnitine in the therapy of dyslipidemic patients. 2007;(4):CD005540. Rossignol, D. A. Drugs Exp Clin Res 1991;17:225-35. View abstract. View abstract. Coulter DL. Nebbioso M, Evangelista M, Librando A, Plateroti AM, Pescosolido N. Iatrogenic dry eye disease: an eledoisin/carnitine and osmolyte drops study. View abstract. View abstract. Am J Mens Health 2021;15(2):15579883211011371. View abstract. Eur.Urol. Effects of L-carnitine supplementation on the quality of life in diabetic patients with muscle cramps. Leuk Lymphoma. Am.J Cardiol. Drugs Exptl Clin Res 1992;18(1):29-36. Bjornsson, E. Hepatotoxicity associated with antiepileptic drugs. Wadzinski, J., Franks, R., Roane, D., and Bayard, M. Valproate-associated hyperammonemic encephalopathy. Drug class: Nutraceutical products. Kidney Int Suppl 1989;27:S259-S263. 2008;42(11):1686-1691. Many studies show that eating eggs regularly can improve health. 2006;132(2):121-128. Ann N Y Acad Sci 2004;1033:99-107. View abstract. 2010;32(8):669-672. Anti-ischaemic efficacy of L-propionylcarnitine - a promising novel metabolic approach to ischaemia? The GOAL study. 2009;6:9. View abstract. View abstract. Brevetti, G., Attisano, T., Perna, S., Rossini, A., Policicchio, A., and Corsi, M. Effect of L-carnitine on the reactive hyperemia in patients affected by peripheral vascular disease: a double-blind, crossover study. Weng Y, Zhang S, Huang W, Xie X, Ma Z, Fan Q. Efficacy of L-Carnitine for Dilated Cardiomyopathy: A Meta-Analysis of Randomized Controlled Trials. Kotby, A. View abstract. View abstract. Although potent on its own, this supplement works best when stacked with other nootropics. Your metabolism determines how many calories you burn each day. Med.Sci Sports Exerc. View abstract. LevOCARNitine (levOCARNitine)." J Infect Dis 1997;176:406-13. Ann N Y Acad Sci 2004;1033:117-31. JPEN J Parenter.Enteral Nutr 1988;12(6):555-562. Drugs Exp Clin Res 1987;13:417-23. Pueschel, S. M. The effect of acetyl-L-carnitine administration on persons with Down syndrome. Mult Scler 2006;12:321-4. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Clin Invest Med. Life Sci 1996;59:1579-99. Garzya G, Corallo D, Fiore A, et al. It plays a crucial role in the production of energy by transporting fatty acids into your cells' mitochondria ( 1, 2, 3 ). J Pediatr Gastroenterol Nutr 1985;4(5):795-798. View abstract. However, one analysis of nine studies mostly in obese individuals or older adults found that people lost an average of 2.9 pounds (1.3 kg) more weight while taking L-carnitine (29). Ghidini O, Azzurro M, Vita G, Sartori G. Evaluation of the therapeutic efficacy of L-carnitine in congestive heart failure. Whats more, five of the participants taking L-carnitine experienced nausea or diarrhea (24). Some dosage forms listed on this page may not apply to the brand name L-Carnitine. View abstract. Laevo-acetylcarnitine (Nicetile registered) treatment of senile depression. Dig Liver Dis 2007;39:922-8. L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial. Moretti S, Alesse E, Di Marzio L, et al. View abstract. Spiekerkoetter, U., Lindner, M., Santer, R., Grotzke, M., Baumgartner, M. R., Boehles, H., Das, A., Haase, C., Hennermann, J. Sima AAF, Calvani M, Mehra M, et al. Phytomedicine. Effects of L-carnitine on leukocyte function and viability in hemodialysis patients: A double-blind randomized trial.